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Protective Bioenergetic Responses of Cardiomyocytes to Hypoxic Stress
Guest Speaker:
Gary L. Wright, Ph.D
Assistant Professor Department of Pharmaceutical Sciences Medical University of South Carolina
The prolyl hydroxylase (PHD) oxygen-sensor has emerged as the central signaling pathway that mediates the cellular response to hypoxia. Elucidation of PHD-directed changes in cellular metabolism is crucial for the understanding the etiology of ischemic pathologies. Learn about the fundamental changes in heart cell metabolism and physiology that comprise the protective metabolic program employed against hypoxic stress.
Also discussed:
- The utility of contracting cardiomyocyte cultures in exploring the mechanisms of drugs that impact metabolic function
- The critical importance of adequate ATP turnover and workload when evaluating mitochondrial metabolism
- The mechanism via which cells down regulate ATP turnover independent from ATP synthesis
View On-Demand Webinar*
References and Additional Links
South Carolina College of Pharmacy Website:
http://www.sccp.sc.edu/index.aspx
Contact Information:
Gary L. Wright, Ph.D
Assistant Professor
Department of Pharmaceutical Sciences
Medical University of South Carolina
Email: wrightgl@musc.edu
*None of the content on this website should be considered medical or psychological advice. Seahorse Biosciences does not give medical advice or diagnose medical and psychological conditions. Although every effort is made to assure that information on this site is accurate and current, knowledge in the field of cellular bioenergetics is growing rapidly and all data is subject to change without notice.
You should consult with your healthcare professional for specific advice relating to your medical questions or conditions. None of the information, statements and/or links contained on the website are intended to replace the attention or medical instructions from a healthcare professional. Only your practitioner can completely and appropriately assess your situation and make conclusive decisions regarding your care.
